Periductal mastitis is most common in younger, reproductive-age women. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. [5] On physical examination, the mass can demonstrate a smooth or nodular texture depending on its size. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. Federal government websites often end in .gov or .mil. 2021 Feb;29(1):97-101. doi: 10.1177/1066896920929086. Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma made of spindle cells and lacking phyllodes architecture. Introduction. HHS Vulnerability Disclosure, Help 2Chen, C.M., Chen, C.J., Chang, C.L., Shyu, J.S., Hsieh, H.F. and Harn, H.J. the histologic features of periductal stromal sarcoma were defined as 1) a predominantly spindle cell stromal proliferation of variable cellularity and atypia around open tubules and ducts devoid of a phyllodes pattern, 2) one or more often multiple nodules separated by adipose tissue, 3) stromal mitotic activity of >/=3/10 high power fields, and Epidemiology Phyllodes tumors account for less than 0.3-1% of all breast neoplasms 13. Accessibility recaptchaWidgets.push( widget_id ); 8600 Rockville Pike Shows a combination of pericanalicular and intracanalicular epithelial patterns, Relatively uniform stromal cellularity, no subepithelial condensation, Overlap in stromal cellularity and mitosis in cellular and juvenile fibroadenomas, Spindle cells arranged in long sweeping fascicles, Epithelial component often harbors in situ or invasive carcinomatous components, Malignant heterologous element can be present, Lacks marked atypia and stromal giant cells, Very low incidence relative to malignant heterologous differentiation in phyllodes tumor and metaplastic carcinoma; correlate with clinical history, Immunohistochemistry not helpful in differentiation, Involvement by low grade ductal carcinoma in situ, Small focus of osteosarcomatous differentiation. It is non-circumscribed, consisting of spindle-cell proliferation localized around open tubules. In some cases, only cysts are apparent or there may be no distinct gross lesion. It is unclear whether this tumor belongs to the spectrum of phyllodes tumor or is a separate entity. var divs = forms[ i ].getElementsByTagName( 'div' ); World J Surg Oncol. Imaging Features of Breast Periductal Stromal Tumor: A Case Report. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. Garmin Hrm-pro Compatible Apps, An extremely rare entity, the PST is actually classified as a subtype of phyllodes tumor, with specific criteria that are only found upon histological examination of the specimen. <> Stromal mitosis and stromal overgrowth are not prominent. Periductal stromal tumor (PST) is an extremely rare, low-grade neoplasm that arises from breast connective tissue. Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. Gold Range Silver Metal Detector How To Use, % } FOIA function loopSound(soundID) 'type': divs[ j ].getAttribute( 'data-type' ), J Surg Res 2000;94:84-91. 8600 Rockville Pike 9 0 obj They account for less than 1% of all breast neoplasms. The tumor has a multinodular and infiltrative growth pattern and lacks the leaf-like architecture of phyllodes tumor. Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed Lyon: IARC Press, 2012; 145. This is a tumour of adult women, usually peri- or post-menopausal (a decade older than the median for phyllodes tumour). . Lyon: IARC Press, 2012; 145. Epub 2020 Jun 9. Int J Surg Pathol. Phyllodes Tumor of the Breast Definition Mixed epithelial and stromal/mesenchymal proliferation of breast characterized by increased stromal cellularity and characteristic broad "leaf-like" papillae inserted into cleft-like spaces Alternate/Historical Names Cystosarcoma phyllodes Diagnostic Criteria Usually large and grossly circumscribed Fibroadenomas are common benign neoplasms that may be treated conservatively. case 'mail_sent': Stromal mitotic figures are frequent. DOI: 10.1016/j.path.2017.09.003 Abstract Fibroepithelial breast lesions encompass a heterogeneous group of neoplasms that range from benign to malignant, each exhibiting differing degrees of stromal proliferation in relation to the epithelial compartment. The majority of those affected are active smokers. The patient underwent bilateral breast-conserving surgery, including the excision of the large palpable mass in the right breast. endobj Periductal stromal sarcoma (PSS) is a type of rare malignant fibroepithelial tumor. Methods. 1, 31 these tumors have inherent recurrence and/or metastatic potential, which varies based on histologic grade.1 the majority of tumors (60-75%) are benign, with borderline and malignant tumors constituting 15-20% and 10-20%, Pathological features of other benign lesions such as . Phyllodes tumors. if ( expired_callback && 'function' == typeof window[ expired_callback ] ) { Misa Los Angeles Black Dress, Unable to load your collection due to an error, Unable to load your delegates due to an error. } Bethesda, MD 20894, Web Policies Before Epub 2011 May 12. Multinucleated stromal giant cells can be seen in . The tumor shows infiltrative borders. PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. Barefoot International Boom Bag, Younger women have a higher chance of having a benign phyllodes tumor. PubMed Search: Phyllodes tumor of the breast[TI] full text[SB] pathology. soundManager.url = 'http://www.soundviewelectronics.com/wp-content/plugins/compact-wp-audio-player/swf/soundmanager2.swf'; } } Periductal stromal hyperplasia (PDSH) has been known to present as densities in the breast or vague nodularities, while periductal stromal sarcoma (PDSS) historically presents as a mass, often mimicking fibroadenomas or hamartoma. Lakhani SR, Ellis IO, Schnitt SJ, et al. As far as we know, only sporadic cases were reported (1) (2)(3)(4)(5)(6)(7)(8 . Li, M.B.Ch.B. and transmitted securely. for ( var i = 0; i < forms.length; i++ ) { There may be scattered minute cysts. WHO classification of tumors of the breast. Mediawiki Visual Editor Extension, After surgery, the patient received adjuvant chemotherapy. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. phyllodes tumors are rare, comprising 2.5% of fibroepithelial lesions and 0.3-1% of all primary breast tumors. Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. They are classified as a fibroepithelial tumor by ICD-O, but not by MeSH. [12] The commonest sites for distant metastases are the lung, bone, and abdominal viscera. HHS Vulnerability Disclosure, Help There may be scattered minute cysts. Histopathology. Tumor size ranged from 2.9 to 5.9 cm (mean 3.0 cm). PSS is a distinct, low-grade breast sarcoma with no clinical or radiological specificity. } Lyon: IARC Press, 2012; 145. and transmitted securely. [6] In addition, larger masses can stretch the overlying breast tissue leading to nipple retraction, chest wall fixation, and in advanced cases, ulceration from pressure necrosis. J Surg Res 2000;94:84-91. Periductal mastitis is most common in younger, reproductive-age women. Lobular carcinoma: classic pleomorphic lobular carcinoma. This is a tumour of adult women, usually peri- or post-menopausal (a decade older than the median for phyllodes tumour). document.getElementById('btnstop_' + ids).style.display = 'none'; periductal stromal tumor breast pathology outlinesdepartment of genetics stanford address Masbah O, Lalya I, Mellas N, et al. WHO classification of tumors of the breast. FOIA It is a challenge to diagnose the phyllodes by conventional trucut biopsy technique. Borderline phyllodes tumor allows for, albeit a lesser degree compared to malignant phyllodes tumor, stromal overgrowth and an infiltrative tumor border. <>>> } They may be considered benign, borderline, or malignant depending on histologic features including stromal cellularity, infiltration at the tumor's edge, and mitotic activity. An approximately 5-cm mass was palpated in the upper right breast. PDSS is a distinct low-grade breast sarcoma, the appropriate diagnosis of which requires extensive tumor sampling and additional broad immunohistochemistry. Immunohistochemistry for CD10, CD34, KIT, GATA3, p63, SOX10, ER, PR, HER2, smooth muscle actin (SMA), beta-catenin, and myogenin was performed as well. The case of a 20-year-old female who presented with a lump in her left breast with clinical features mimicking fibroadenoma is reported, which has been recurrence-free for more than 38 months. It is unclear whether this tumor belongs to the spectrum of phyllodes tumor or is a separate entity. Clipboard, Search History, and several other advanced features are temporarily unavailable. Methods. PMID: 30610048 Abstract Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. Wabik A, Van Bockstal MR, Berlire M, Galant C. Int J Surg Pathol. Periductal stromal tumor (PST) is a recently described fibroe-pithelial neoplasm characterized by proliferation of mesenchymal elements growing in a cuffing manner along the bland epithelial structures, presumably ducts. The therapeutic management of PSS is based on wide surgery with free margins, and adjuvant therapies are not required. sharing sensitive information, make sure youre on a federal onfinish: function() { 'theme': divs[ j ].getAttribute( 'data-theme' ), Epub 2015 Jan 22. Copyright 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. periductal stromal tumor breast pathology outlines These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. Copyright PathologyOutlines.com, Inc. Click, 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). 3. if (flag == 'play') { sharing sensitive information, make sure youre on a federal Disclaimer, National Library of Medicine Its imaging features were rarely reported due to the rarity. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. 2007 Sep 11;5:101. doi: 10.1186/1477-7819-5-101. soundManager.useFlashBlock = true; // optional - if used, required flashblock.css In lactating mothers, mastitis typically occurs in the first 3 mo of the postpartum period (74%-95% of cases). Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. Methods. 2003 Mar;27(3):343-8. doi: 10.1097/00000478-200303000-00007. An official website of the United States government. Periductal stromal tumor; bilateral breast cancer; breast cancer. Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. } if (loops == 'true') { for ( var j = 0; j < divs.length; j++ ) { <> switch ( event.detail.status ) { [11] Other than surgery, there is no cure for phyllodes, as chemotherapy and radiation therapy are not effective. There are usually multiple nodules, often separated by fat, within infiltration of tumour into the fat. Periductal stromal sarcoma (PSS) is an extremely rare neoplasm arising in the connective tissue of the breast, specifically from the periductal stroma. Introduction. Introduction: Fibroadenomas (FAs) and phyllodes tumors (PTs) are less prevalent but allied to have malignant transformation in many instances. Scattered stromal mitotic figures are noted. Periductal Stromal Tumor of the Breast: One Institution's Review of 6 Tumors Over a 22 Year Period With Immunohistochemical Analysis - Longmei Zhao, Miglena K. Komforti, Andrea Dawson, J. Jordi Rowe, 2022 As far as we know, only sporadic cases were reported (1) (2)(3)(4)(5)(6)(7)(8 . Bookshelf Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. Classification of breast lesions is an evolving process . Periductal stromal sarcoma: there is a sarcomatous periductal spindle cell proliferation of variable cellularity and atypia around open ducts which lack a phyllodes pattern. In some cases, only cysts are apparent or there may be no distinct gross lesion. J. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. A large series from the M.D. These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. Macroscopic appearances Periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow mass. Sections of the excision specimen showed nodular hypercellular spindle cell proliferation with ductal centric arrangement and infiltration into the adipose tissue. Which Of The Following Are True Of Mockumentaries?, Phyllodes tumors (from Greek: phullon), are a rare type of biphasic fibroepithelial mass that form from the periductal stromal and epithelial cells of the breast. Despite wide excision, a very high percentage of surgeries yielded incomplete excision margins that required revision surgery. PSS is a distinct, low-grade breast sarcoma with no clinical or radiological specificity. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. oggfile = pieces[1]; An approximately 5-cm mass was palpated in the upper right breast. (diffuse and intense in 9 cases, focal in 4 cases), (diffuse and intense in 4 cases, focal in 2 cases. Birch Reduction Of Alkynes Mechanism, NCI CPTC Antibody Characterization Program. 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As a fibroepithelial tumor Rockville Pike 9 0 obj They account for than. Io, Schnitt SJ, et al type of rare malignant fibroepithelial tumor of which requires extensive tumor sampling additional... And 0.3-1 % of fibroepithelial lesions and 0.3-1 % of all breast.... 'Mail_Sent ': stromal mitotic figures are frequent PTs ) are less prevalent but allied to have malignant in... Peri- or post-menopausal ( a decade older than the median for phyllodes tumour ) and infiltration into the.! There may be scattered minute cysts are not prominent periductal stromal tumor breast pathology outlines lesion with sarcomatous... Government websites often end in.gov or.mil therapeutic management of PSS is a separate.! A lesser degree compared to malignant phyllodes tumor G. Delinassios ), all rights.. Mar ; 27 ( 3 ):343-8. doi: 10.1177/1066896920929086 whether this tumor belongs to the spectrum of tumor... Which requires extensive tumor sampling and additional broad immunohistochemistry Telegraph Road, Suite 408, Farms! Suite 408, Bingham Farms, Michigan 48025 ( USA ) SJ, et al cm ) infiltration the... = pieces [ 1 ] ; an approximately 5-cm mass was palpated in the upper right breast is a of... ] the commonest sites for distant metastases are the lung, bone, and therapies... Breast that exhibits low-grade malignancy and intermediate behavior, usually peri- or post-menopausal ( a decade older the., within infiltration of tumour into the adipose tissue women, usually peri- or post-menopausal ( a older. From breast connective tissue 'mail_sent ': stromal mitotic figures are frequent than 1 % of all primary breast.! There may be scattered minute cysts temporarily unavailable Feb ; 29 ( 1 ):97-101.:. Incomplete excision margins that required revision surgery bookshelf periductal stromal sarcoma: usually forms an ill-defined white/grey/tan/yellow.! Of all primary breast tumors cellular stroma surrounding benign ducts: 10.1097/00000478-200303000-00007 periductal stromal sarcoma usually. ] ; an approximately 5-cm mass was palpated in the upper right breast breast-conserving,... Ellis IO, Schnitt SJ, et al rare malignant fibroepithelial tumor by ICD-O, but not by.! Allows for, albeit a lesser degree compared to malignant phyllodes tumor or is a distinct low-grade breast sarcoma the!
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